Gene expression systems built around your therapy.
Your therapeutic gene needs to be active in the right cells, at the right level and under the right conditions. Standard regulatory sequences, including viral promoters, often do not provide that level of control.
Annogen develops and validates tailored expression systems through high-throughput screening, computational optimization, and experimental validation in relevant vitro and vivo models. With more than a decade of experience, including the design of promoters used by leading biopharma companies and in clinical-stage applications, Annogen helps you identify the promoter that best fits your therapy.
Exhaustive screening and design of bespoke promoters and integration sites for any tissue, any organism.
Identify which sequence changes are most likely to influence gene expression by evaluating candidate variants experimentally, so decisions rest on functional evidence rather than prediction alone.
Empirically screening for the most optimal non-coding elements including 3’UTRs, insulators, and silencers.
Identify which sequence changes are most likely to influence gene expression by evaluating candidate variants experimentally, so decisions rest on functional evidence rather than prediction alone.
Improve titers and expression stability in manufacturing cell lines for recombinant proteins and viral vectors.
Generate bespoke, highly sensitive data sets to train and improve your ML/AI models.
Gene expression systems build around your therapy.
Gene expression shapes the safety and efficacy of any cell or gene therapy. Standard regulatory sequences including viral promoters often do not give you the control your program needs. Annogen has a decade of experience, developing and validating expression systems through screenings performed directly in relevant vitro and in vivo models. Our promoters are used by leading biopharma companies, and some are already used in clinical stage therapies.
We imagine there could be some questions you want to ask us. Discover the most frequently asked questions about this subject right here.
Annogen is your partner in designing gene expression systems for any application, for any cell type. We move beyond assumptions and standard solutions relying instead on design-test iterations at scale in the relevant in vitro and in vivo models.
Our approach makes gene expression designable, so outcomes are no longer left to chance but deliberately shaped. We deliver validated expression systems and eliminate the need for lengthy in-house development.
We combine high-throughput experimental screening with AI-based optimizations to identify what performs, not just what looks promising in a model.
With more than a decade of promoter development experience, we can assess feasibility early, guide realistic timelines, and tell you when expectations need adjusting.
When existing data does not cover your needs, we generate the dataset your promoter design needs in the most appropriate cell type and model system.
We don’t settle for good enough. Using our data generation capabilities, we explore the full design space to understand what works best, instead of generating quick designs based on limited available data.
Everything we do is grounded in real experimental data. No black boxes, no guesswork. We deliver validated designs rather than predictions to be validated.
We believe biological systems can be understood, designed, and controlled. That belief drives how we design, test and optimize our gene expression systems.
Design gene expression around two critical choices: the regulatory sequence that controls your gene, and the genomic location where it performs.
Find the genomic locations where your transgene performs reliably.
AIM™ maps integration sites at scale while in parallel measuring expression for each site. This reveals where expression is stable, controlled, and best suited to your system.
Find the regulatory sequences that give your gene the right expression behavior.
SuRE™ screens promoters, enhancers and regulatory variants at scale to identify what delivers the right strength, specificity and control.
Exhaustive screening and design of bespoke promoters and expression loci for any tissue, any organism. We believe control of gene expression is the foundation of the next generation of therapeutics and crops.
